From the Editor
Is new better?
You may be reading this on an iPhone 7, having driven to work this morning in a 2017 Hybrid Prius. So should your patients be taking a medication that became available four-and-a-half decades ago – when people drove gus-gusling eight-cylinder Oldsmobiles and smartphones didn’t even exist in science fiction novels.
This week, we look at a just-published JAMA Psychiatry paper which promises to look at the “real-world” effectiveness of antipsychotics. The authors tapped Swedish databases to consider outcomes for nearly thirty thousand people with schizophrenia.
Sweden: elaborate welfare state, beautiful historic buildings, and – yes – rich databases
Spoiler alert: new wasn’t better. That is, newer antipsychotics tended to underperform clozapine and depot medications.
We also look at similar “real-world” work drawing from a Finnish database considering treatment of depression.