Tagdementia

Reading of the Week: Can Lithium in Drinking Water Help Prevent Dementia? The Kessing et al. Paper from JAMA Psychiatry

From the Editor

Since the extraordinary work of John Cade some seven decades ago, lithium has been used as a medication to help people with bipolar. But the history of lithium use is longer – for many years, people have understood that it has medicinal value, and bottled water containing lithium was popular at the turn of the twentieth century (long before Dr. Cade started medical school).

We know that lithium affects the brain in many ways (for example, it slows apoptosis, or programmed cell death); we also that know that dementia can work on those same pathways, but in a negative way (it may sped up apoptosis). In this week’s selection, the authors wonder if lithium can prevent dementia. It’s a big question – and the authors tap a big national database. They find a non-linear correlation between lithium in drinking water and dementia.

Tap water: A potential prevention for dementia if it has lithium in it?

So – does this paper represent something of a breakthrough? We look at the paper and an editorial to answer that question.

DG Continue reading

Reading of the Week: The Good Life of Oliver Sacks, and More

From the Editor

Is the incidence of dementia falling?

What makes a good clinician?

This week, I’ve selected two Readings. We open with a NEJM paper suggesting a big trend: a decline in the incidence of dementia. That paper obviously has major implications for public policy. We then move on to a big and eloquent essay on a famous doctor, Oliver Sacks.

There isn’t much connecting these selections – except that both were suggested by readers, and they both raise big questions.

Enjoy.

DG Continue reading